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Stopping Mounjaro, Ozempic: What’s the Weight Loss Fallout?


Stopping Mounjaro and Ozempic: What Happens When You Cease Taking Weight Loss Drugs

The use of weight loss drugs like Ozempic and Mounjaro has become increasingly popular, with over half a million Brits thought to be relying on these medications to shed pounds. These drugs work by mimicking the hormones associated with feeling hungry and reducing appetite, leading to significant weight loss in many cases. However, as with any medication, there are potential health risks and side effects, and it is essential to consider what happens when you stop taking these weight loss drugs.

According to the NHS, patients should only take semaglutide, the scientific name for Ozempic, for a maximum of two years. However, recent studies have found that many people who stop taking weight loss drugs return to their original weight within a year. Researchers at the University of Oxford examined data from various studies and found that most people lost around 8kg but gained it back within 10 months. Those taking newer weight loss drugs lost even more weight but were expected to regain weight within less than two years.

The duration for which people use weight loss drugs will vary from case to case, and it is best agreed upon with guidance from a GP. In most cases, it’s seen as a long-term process and designed to be taken for a prolonged duration. Most patients don’t tend to start seeing results until after using the injectables for at least four weeks, or longer. However, according to the National Institute for Health and Care Excellence (NICE), semaglutide should not be taken for more than two years.

There are many reasons why a person would choose to stop taking such weight therapies, with some people reporting side effects or it being too expensive. Under new rules coming into effect on June 1, to obtain weight loss drugs, patients must now have face-to-face consultations with a nurse or a medical expert. According to Dr. Ola Otulana, a GP and Addiction Specialist Physician from Cassiobury Court, people should focus on maintaining an overall healthy lifestyle to reduce the chance of weight gain after stopping such drugs.

"Maintaining weight after stopping these medications requires a strong focus on lifestyle interventions," he told The Evening Standard. "Particularly a healthy, balanced diet and consistent physical activity. Ongoing support from a dietitian or healthcare provider can also be effective. Behavioural strategies such as meal planning or portion control and monitoring weight regularly can help sustain weight loss."

The GP also suggested that some people could ‘gradually transition’ off the medication, but only under the supervision of a doctor. When stopping weight loss drugs, it takes a number of days for the effects of semaglutide and tirzepatide to leave a person’s system. Cravings and hunger might then start to return, and people don’t feel as full anymore. A lot of people will regain some weight during this time, and people’s cholesterol and blood pressure levels can also return to previous levels.

As the demand for injectable glucagon-like peptide-1 (GLP-1) injections continues to grow, studies into the impact of Ozempic and Mounjaro are still ongoing, with researchers increasingly trying to understand the long-term effects of use. Experts stress that more research is needed to fully comprehend the effects of these medications. In the meantime, it is crucial for individuals considering weight loss drugs to consult their doctors first and discuss the potential risks and benefits.

In conclusion, while weight loss drugs like Ozempic and Mounjaro can be effective in achieving significant weight loss, it is essential to be aware of the potential consequences of stopping these medications. By maintaining a healthy lifestyle and receiving ongoing support from healthcare professionals, individuals can reduce their chances of weight gain and ensure a sustainable weight loss journey.

The Evening Standard spoke to Dr. Ola Otulana, a GP and Addiction Specialist Physician from Cassiobury Court, who provided expert insights on the matter. The article is based on information from various sources, including The Guardian and NBC, as well as research from the University of Oxford.

As weight loss drugs continue to gain popularity, it is vital to stay informed about their effects, benefits, and potential drawbacks. This article aims to provide readers with a comprehensive understanding of what happens when stopping weight loss drugs like Mounjaro and Ozempic, and what individuals can do to maintain a healthy weight in the long term.

Studies have shown that a combination of a healthy diet, regular physical activity, and behavioural strategies can help sustain weight loss. As research continues to uncover the long-term effects of weight loss drugs, individuals must prioritize their health and wellbeing by making informed decisions about their treatment options.

Ultimately, while weight loss drugs can be an effective tool in achieving weight loss, it is essential to approach their use with caution and under the guidance of a healthcare professional. By doing so, individuals can minimize potential risks and maximize the benefits of these medications.



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